Genome-wide linkage analysis for uric acid in families enriched for hypertension Academic Article uri icon

Overview

MeSH Major

  • Genetic Linkage
  • Genome, Human
  • Hypertension
  • Uric Acid

abstract

  • Several novel loci linked to uric acid were identified but none showed clear replication. Widespread diuretic use, a medication that raises uric acid levels, was an important study limitation. Bivariate linkage analyses and pathway analysis were consistent with genes regulating insulin resistance and fructose metabolism contributing to the heritability of uric acid.

publication date

  • August 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2734170

Digital Object Identifier (DOI)

  • 10.1093/ndt/gfp080

PubMed ID

  • 19258383

Additional Document Info

start page

  • 2414

end page

  • 20

volume

  • 24

number

  • 8