Maternal administration of anti-angiogenic agents, TNP-470 and angiostatin4.5, induces fetal microphthalmia Academic Article uri icon

Overview

MeSH Major

  • Angiogenesis Inhibitors
  • Angiostatins
  • Cyclohexanes
  • Fetal Diseases
  • Microphthalmos
  • Sesquiterpenes
  • Teratogens

abstract

  • These experiments support the hypothesis that the angiogenic inhibitors (specifically TNP-470 and AS(4.5)) induce microphthalmia either indirectly by their known effects on placental morphology (and/or function) or directly via altering microvascular growth in the fetus. These results also warrant further investigation of a new experimental paradigm linking placental pathology-related fetal growth restriction and microphthalmia.

publication date

  • June 26, 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2704144

PubMed ID

  • 19572040

Additional Document Info

start page

  • 1260

end page

  • 9

volume

  • 15