Local cytokine profiles in knee osteoarthritis: elevated synovial fluid interleukin-15 differentiates early from end-stage disease Academic Article uri icon

Overview

MeSH Major

  • Cartilage, Articular
  • Cytokines
  • Interleukin-15
  • Osteoarthritis, Knee
  • Synovial Fluid
  • Synovial Membrane

abstract

  • IL-15 is elevated in early knee OA, suggesting activation of an innate immune response in the SM. The association of IL-15 expression with CD8 transcripts and MMPs implicates this cytokine in OA pathogenesis and as a candidate therapeutic target.

publication date

  • August 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.joca.2009.02.011

PubMed ID

  • 19289234

Additional Document Info

start page

  • 1040

end page

  • 8

volume

  • 17

number

  • 8