Mutant LRRK2R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease Academic Article uri icon

Overview

MeSH Major

  • Disease Models, Animal
  • Mice, Transgenic
  • Parkinson Disease
  • Protein-Serine-Threonine Kinases

abstract

  • Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal features of the disease: an age-dependent and levodopa-responsive slowness of movement associated with diminished dopamine release and axonal pathology of nigrostriatal dopaminergic projection. These mice provide a valid model of Parkinson's disease and are a resource for the investigation of pathogenesis and therapeutics.

publication date

  • July 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2845930

Digital Object Identifier (DOI)

  • 10.1038/nn.2349

PubMed ID

  • 19503083

Additional Document Info

start page

  • 826

end page

  • 8

volume

  • 12

number

  • 7