Investigation of the locus near MC4R with childhood obesity in Americans of European and African ancestry Academic Article uri icon

Overview

MeSH Major

  • African Americans
  • European Continental Ancestry Group
  • Obesity
  • Polymorphism, Single Nucleotide
  • Receptor, Melanocortin, Type 4

abstract

  • Recently a modest, but consistently, replicated association was demonstrated between obesity and the single-nucleotide polymorphism (SNP), rs17782313, 3' of the MC4R locus as a consequence of a meta-analysis of genome-wide association (GWA) studies of the disease in white populations. We investigated the association in the context of the childhood form of the disease utilizing data from our ongoing GWA study in a cohort of 728 European-American (EA) obese children (BMI > or =95th percentile) and 3,960 EA controls (BMI <95th percentile), as well as 1,008 African-American (AA) obese children and 2,715 AA controls. rs571312, rs10871777, and rs476828 (perfect surrogates for rs17782313) yielded odds ratios in the EA cohort of 1.142 (P = 0.045), 1.137 (P = 0.054), and 1.145 (P = 0.042); however, there was no significant association with these SNPs in the AA cohort. When investigating all 30 SNPs present on the Illumina BeadChip at this locus, again there was no evidence for association in AA cases when correcting for the number of tests employed. As such, variants 3' to the MC4R locus present on the genotyping platform utilized confer a similar magnitude of risk of obesity in white children as to their adult white counterparts but this observation did not extend to AAs.

publication date

  • July 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2860794

Digital Object Identifier (DOI)

  • 10.1038/oby.2009.53

PubMed ID

  • 19265794

Additional Document Info

start page

  • 1461

end page

  • 5

volume

  • 17

number

  • 7