Treatment of acute bacterial exacerbations of chronic bronchitis Review uri icon

Overview

MeSH Major

  • Adrenal Cortex Hormones
  • Anti-Bacterial Agents
  • Bronchitis
  • Bronchodilator Agents

abstract

  • Administration of antimicrobial agents, combined with bronchodilators and systemic corticosteroids, is warranted in approximately half of AECBs (i.e., in bacterial exacerbations) to achieve a survival benefit. Simple clinical parameters, mainly sputum purulence, and biomarkers, such as procalcitonin, are useful in identifying patients requiring antibiotics. Advanced antibiotics (quinolones, macrolides, or amoxicillin/clavulanic acid) are more effective than 'old' antibiotics in AECB; regimens of short duration (for 5 days) are preferred. There is no difference between several classes of advanced antibiotics regarding their short-term effectiveness; however, quinolones are associated with better long-term outcomes than macrolides. Newer quinolones and new formulations of macrolides enrich clinicians' armamentarium against AECB.

publication date

  • May 2009

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1517/14656560902907734

PubMed ID

  • 19405791

Additional Document Info

start page

  • 1173

end page

  • 82

volume

  • 10

number

  • 7