Mitochondrial membrane permeabilization in neuronal injury Review uri icon

Overview

MeSH Major

  • Mitochondrial Membranes
  • Neurons

abstract

  • Acute neurological conditions such as cerebrovascular diseases and trauma are associated with irreversible loss of neurons and glial cells. Severe or prolonged injury results in uncontrollable cell death within the core of lesions. Conversely, cells that are less severely damaged succumb in a relatively slow fashion, frequently via the intrinsic pathway of cell death, through the deterioration of mitochondrial functions. The permeabilization of mitochondrial membranes determines whether cells will succumb to or survive the injury, and represents a 'point of no return' in mitochondrial cell death. It is therefore an attractive target for the development of new neuroprotective interventions.

publication date

  • July 2009

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1038/nrn2665

PubMed ID

  • 19543220

Additional Document Info

start page

  • 481

end page

  • 94

volume

  • 10

number

  • 7