IL-22-producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells Academic Article uri icon

Overview

MeSH Major

  • Dermatitis, Atopic
  • Interleukin-23
  • Interleukins
  • Psoriasis
  • T-Lymphocyte Subsets
  • T-Lymphocytes, Helper-Inducer

abstract

  • Our data established that T cells could independently express IL-22 even with low expression levels of IL-17. This argues for a functional specialization of T cells such that "T17" and "T22" T-cells may drive different features of epidermal pathology in inflammatory skin diseases, including induction of antimicrobial peptides for "T17" T cells and epidermal hyperplasia for "T22" T-cells. Given the clinical correlation with disease severity, further characterization of "T22" T cells is warranted, and may have future therapeutic implications.

publication date

  • June 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2874584

Digital Object Identifier (DOI)

  • 10.1016/j.jaci.2009.03.041

PubMed ID

  • 19439349

Additional Document Info

start page

  • 1244

end page

  • 52.e2

volume

  • 123

number

  • 6