p16INK4A immunohistochemical staining may be helpful in distinguishing branchial cleft cysts from cystic squamous cell carcinomas originating in the oropharynx Academic Article uri icon

Overview

MeSH Major

  • Branchioma
  • Carcinoma, Squamous Cell
  • Cyclin-Dependent Kinase Inhibitor p16
  • Head and Neck Neoplasms
  • Oropharynx

abstract

  • Branchial cleft cysts can exhibit focal strong reactivity limited to the superficial squamous epithelium and glandular epithelium. Although p16(INK4A) immunohistochemistry may be helpful in distinguishing oropharyngeal nonkeratinizing SCC from branchial cleft cysts in FNAB specimens, it is not helpful in cases of keratinizing SCC because these cases are typically negative for p16(INK4A).

publication date

  • December 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2933039

Digital Object Identifier (DOI)

  • 10.1002/cncy.20001

PubMed ID

  • 19365840

Additional Document Info

start page

  • 108

end page

  • 19

volume

  • 117

number

  • 2