Antitumor effects and biomarkers of activity of AZD0530, a Src inhibitor, in pancreatic cancer Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Benzodioxoles
  • Biomarkers, Tumor
  • Pancreatic Neoplasms
  • Proto-Oncogene Proteins pp60(c-src)
  • Quinazolines

abstract

  • AZD0530 treatment significantly inhibits the tumor growth in a subset of human pancreatic tumor xenografts. One gene pair (LRRC19 and IGFBP2) identified by the K-TSP classifier has high predictive power for AZD0530 sensitivity, suggesting the potential for this gene pair as biomarker for pancreatic tumor sensitivity to AZD0530.

publication date

  • June 15, 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-08-3021

PubMed ID

  • 19509160

Additional Document Info

start page

  • 4138

end page

  • 46

volume

  • 15

number

  • 12