Common genetic variants on 5p14.1 associate with autism spectrum disorders Academic Article uri icon

Overview

MeSH Major

  • Autistic Disorder
  • Chromosomes, Human, Pair 5
  • Genetic Predisposition to Disease
  • Genetic Variation

abstract

  • Autism spectrum disorders (ASDs) represent a group of childhood neurodevelopmental and neuropsychiatric disorders characterized by deficits in verbal communication, impairment of social interaction, and restricted and repetitive patterns of interests and behaviour. To identify common genetic risk factors underlying ASDs, here we present the results of genome-wide association studies on a cohort of 780 families (3,101 subjects) with affected children, and a second cohort of 1,204 affected subjects and 6,491 control subjects, all of whom were of European ancestry. Six single nucleotide polymorphisms between cadherin 10 (CDH10) and cadherin 9 (CDH9)-two genes encoding neuronal cell-adhesion molecules-revealed strong association signals, with the most significant SNP being rs4307059 (P = 3.4 x 10(-8), odds ratio = 1.19). These signals were replicated in two independent cohorts, with combined P values ranging from 7.4 x 10(-8) to 2.1 x 10(-10). Our results implicate neuronal cell-adhesion molecules in the pathogenesis of ASDs, and represent, to our knowledge, the first demonstration of genome-wide significant association of common variants with susceptibility to ASDs.

authors

publication date

  • May 28, 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2943511

Digital Object Identifier (DOI)

  • 10.1038/nature07999

PubMed ID

  • 19404256

Additional Document Info

start page

  • 528

end page

  • 33

volume

  • 459

number

  • 7246