Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis Comment uri icon

Overview

MeSH Major

  • Oncogene Proteins, Fusion
  • Phosphatidylinositol 3-Kinases
  • Prostate
  • Prostatic Neoplasms
  • Signal Transduction

abstract

  • The TMPRSS2-ERG fusion, present in approximately 50% of prostate cancers, is less common in prostatic intraepithelial neoplasia (PIN), raising questions about whether TMPRSS2-ERG contributes to disease initiation. We identified the translational start site of a common TMPRSS2-ERG fusion and showed that transgenic TMPRSS2-ERG mice develop PIN, but only in the context of PI3-kinase pathway activation. TMPRSS2-ERG-positive human tumors are also enriched for PTEN loss, suggesting cooperation in prostate tumorigenesis.

publication date

  • May 2009

Research

keywords

  • Comment

Identity

Digital Object Identifier (DOI)

  • 10.1038/ng.371

PubMed ID

  • 19396167

Additional Document Info

start page

  • 524

end page

  • 6

volume

  • 41

number

  • 5