Effects of chemotherapy in AIDS-associated non-Hodgkin's lymphoma on Kaposi's sarcoma herpesvirus DNA in blood Academic Article uri icon

Overview

MeSH Major

  • Acquired Immunodeficiency Syndrome
  • Antineoplastic Agents
  • DNA, Viral
  • Herpesvirus 8, Human
  • Lymphoma, AIDS-Related
  • Lymphoma, Non-Hodgkin

abstract

  • KSHV DNA is sometimes detected in PBMC or in plasma of patients with AIDS-NHL without KS. Among patients with KSHV DNA detected in PBMC or in plasma, copy number does not distinguish between patients with AIDS-NHL and AIDS-KS. KSHV DNA in plasma likely reflects viremia and not simply lysis of tumor or other KSHV-infected cells. KSHV DNA copy number in PBMC and in plasma declined with lymphoma-directed cytotoxic chemotherapy in each of the six patients studied.

publication date

  • May 20, 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2684854

Digital Object Identifier (DOI)

  • 10.1200/JCO.2008.20.1707

PubMed ID

  • 19349542

Additional Document Info

start page

  • 2496

end page

  • 502

volume

  • 27

number

  • 15