varDB: common ground for a shifting landscape. Academic Article uri icon

Overview

MeSH

  • Animals
  • Bacteria
  • Databases, Genetic
  • Eukaryota
  • Fungi
  • HIV
  • Humans
  • Structure-Activity Relationship

MeSH Major

  • Antigenic Variation
  • Databases, Protein
  • Proteins

abstract

  • Antigenic variation is a phylogenetically widespread phenomenon thought to lead to survival benefits for the pathogen. Although governed by genetic mechanisms, antigenic variation is ultimately manifested in variant proteins. The varDB database is an attempt to gain an overview of common structures and functions of variant proteins related to enhanced survival. varDB provides a wealth of sequence data and several tools to facilitate their analysis, but current limitations preclude achievement of its full promise. A critique of this database and how it could serve the scientific community is provided here.

publication date

  • June 2009

has subject area

  • Animals
  • Antigenic Variation
  • Bacteria
  • Databases, Genetic
  • Databases, Protein
  • Eukaryota
  • Fungi
  • HIV
  • Humans
  • Proteins
  • Structure-Activity Relationship

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3697053

Digital Object Identifier (DOI)

  • 10.1016/j.pt.2009.03.003

PubMed ID

  • 19423393

Additional Document Info

start page

  • 249

end page

  • 252

volume

  • 25

number

  • 6