Relationship between health-related quality of life and SLE activity and damage in children over time Academic Article uri icon


MeSH Major

  • Health Status
  • Lupus Erythematosus, Systemic
  • Quality of Life
  • Sickness Impact Profile


  • We previously described the development and validation of the 'Simple Measure of the Impact of Lupus Erythematosus in Youngsters' (SMILEY) for the reliable assessment of health-related quality of life (HRQOL) in children with systemic lupus erythematosus (SLE). The objectives of this new study were to determine the relationship of SMILEY scores to patient's/parent's assessment of HRQOL and SLE status, and physician's assessment of disease activity and damage over time. In this multicentre study, 68 children with SLE and parents completed SMILEY including the global HRQOL and SLE status assessments, physicians completed disease activity and damage tools at two time-points. Spearman rho was calculated between SMILEY scores and other scales, and between interval changes in SMILEY scores and other scales. SMILEY scores correlated with patient/parent assessments of global HRQOL and SLE status, disease activity and damage, confirming previous findings. The change in disease activity and damage measures correlated most strongly with the changes in SMILEY domains, Limitation and Burden of SLE. Results provide preliminary evidence that Limitation and Burden of SLE domains of SMILEY reflect the impact of disease activity and damage on HRQOL.

publication date

  • May 26, 2009



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1177/0961203308101718

PubMed ID

  • 19433463

Additional Document Info

start page

  • 622

end page

  • 9


  • 18


  • 7