Reliability of quantitative sudomotor axon reflex testing and quantitative sensory testing in neuropathy of impaired glucose regulation Academic Article uri icon


MeSH Major

  • Electrodiagnosis
  • Glucose Intolerance
  • Motor Neurons
  • Peripheral Nervous System Diseases
  • Sweat Glands


  • Reproducible neurophysiologic testing paradigms are critical for multicenter studies of neuropathy associated with impaired glucose regulation (IGR), yet the best methodologies and endpoints remain to be established. This study evaluates the reproducibility of neurophysiologic tests within a multicenter research setting. Twenty-three participants with neuropathy and IGR were recruited from two study sites. The reproducibility of quantitative sudomotor axon reflex test (QSART) and quantitative sensory test (QST) (using the CASE IV system) was determined in a subset of patients at two sessions, and it was calculated from intraclass correlation coefficients (ICCs). QST (cold detection threshold: ICC=0.80; vibration detection threshold: ICC=0.75) was more reproducible than QSART (ICC foot=0.52). The performance of multiple tests in one setting did not improve reproducibility of QST. QST reproducibility in our IGR patients was similar to reports of other studies. QSART reproducibility was significantly lower than QST. In this group of patients, the reproducibility of QSART was unacceptable for use as a secondary endpoint measure in clinical research trials.

publication date

  • April 2009



  • Academic Article



  • eng

PubMed Central ID

  • PMC4421877

Digital Object Identifier (DOI)

  • 10.1002/mus.21210

PubMed ID

  • 19260066

Additional Document Info

start page

  • 529

end page

  • 35


  • 39


  • 4