Urachal carcinoma: A clinicopathologic analysis of 24 cases with outcome correlation Academic Article uri icon


MeSH Major

  • Carcinoma
  • Urachus
  • Urinary Bladder Neoplasms
  • Urothelium


  • Pathologic stage is an important prognostic factor in urachal carcinoma. Surface urothelial involvement by carcinoma and presence of cystitis cystica/glandularis do not necessarily exclude the diagnosis of urachal carcinoma. Immunostains do not unequivocally discriminate a urachal from a colorectal carcinoma, but diffuse positivity for 34BE12 would support, and diffuse nuclear immunoreactivity for beta-catenin would militate against, a diagnosis of urachal carcinoma. Local recurrence may be owing to seeding within the distal urothelial tract, particularly in tumors with a configuration that is polypoid and which open into the bladder cavity. The type of surgery performed may have an effect on local recurrence despite negative margins of resection.

publication date

  • May 2009



  • Academic Article



  • eng

PubMed Central ID

  • PMC4225778

Digital Object Identifier (DOI)

  • 10.1097/PAS.0b013e31819aa4ae

PubMed ID

  • 19252435

Additional Document Info

start page

  • 659

end page

  • 68


  • 33


  • 5