Functional MRI and response inhibition in children exposed to cocaine in utero Academic Article uri icon


MeSH Major

  • Cocaine
  • Cocaine-Related Disorders
  • Prenatal Exposure Delayed Effects


  • This study investigated the potential long-term effects of cocaine exposure on brain functioning using fMRI in school-aged children. The sample included 12 children with prenatal cocaine exposure and 12 non-exposed children (8-9 years old). Groups did not differ on IQ, socioeconomic status, or perinatal risk factors. A response inhibition task was administered during an fMRI scan using a 1.5-T MRI system. Task performance did not differentiate groups, but groups were differentiated by patterns of task-related brain activity. Cocaine-exposed children showed greater activation in the right inferior frontal cortex and caudate during response inhibition, whereas non-exposed children showed greater activations in temporal and occipital regions. These preliminary findings suggest that prenatal cocaine may affect the development of brain systems involved in the regulation of attention and response inhibition.

publication date

  • April 2009



  • Academic Article



  • eng

PubMed Central ID

  • PMC2951722

Digital Object Identifier (DOI)

  • 10.1159/000207503

PubMed ID

  • 19372696

Additional Document Info

start page

  • 159

end page

  • 66


  • 31


  • 1-2