Reflex UroVysion testing in suspicious urine cytology cases
Carcinoma, Transitional Cell
In Situ Hybridization, Fluorescence
Urinary Bladder Neoplasms
A negative UroVysion test did not rule out the presence of low-grade or high-grade urothelial carcinoma in urine specimens diagnosed as suspicious. The use of less strict criteria dramatically increased the sensitivity of UroVysion FISH; however, there was a marked decrease in specificity noted. The results in this current study appear to indicate that a more aggressive workup of patients with a suspicious cytology, positive UroVysion result, and negative cystoscopic evaluation is not currently justified.