When starting over makes more sense Academic Article uri icon

Overview

MeSH Major

  • Peptide Chain Termination, Translational
  • Ribosomes

abstract

  • Proofreading mechanisms intrinsic to DNA and RNA polymers that contribute substantially to overall fidelity are lacking in the ribosome. New evidence, however, suggests that quality control in translation can occur after substrate incorporation by an abortive mechanism entailing premature release factor-catalyzed termination. These data shed new light on the importance and ubiquity of retrospective quality control mechanisms in ensuring the overall fidelity of nature's processive enzymes and demonstrate that competitive elongation reactions on the ribosome are kinetically sensitive to compositional features of the translating particle.

publication date

  • February 20, 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3433159

Digital Object Identifier (DOI)

  • 10.1021/cb900030w

PubMed ID

  • 19228069

Additional Document Info

start page

  • 89

end page

  • 92

volume

  • 4

number

  • 2