Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients Academic Article uri icon

Overview

MeSH Major

  • Blood Vessels
  • Hypoxia
  • Inflammation
  • Obesity
  • Vasodilation

abstract

  • We conclude that adipocytes secrete adiponectin and provide the first functional evidence that it is a physiological modulator of local vascular tone by increasing nitric oxide bioavailability. This capacity is lost in obesity by the development of adipocyte hypertrophy, leading to hypoxia, inflammation, and oxidative stress.

publication date

  • March 31, 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/CIRCULATIONAHA.108.821181

PubMed ID

  • 19289637

Additional Document Info

start page

  • 1661

end page

  • 70

volume

  • 119

number

  • 12