In vivo analysis of dendritic cell development and homeostasis Academic Article uri icon


MeSH Major

  • Dendritic Cells
  • Lymphoid Tissue
  • Monocytes
  • Myeloid Progenitor Cells


  • Dendritic cells (DCs) in lymphoid tissue arise from precursors that also produce monocytes and plasmacytoid DCs (pDCs). Where DC and monocyte lineage commitment occurs and the nature of the DC precursor that migrates from the bone marrow to peripheral lymphoid organs are unknown. We show that DC development progresses from the macrophage and DC precursor to common DC precursors that give rise to pDCs and classical spleen DCs (cDCs), but not monocytes, and finally to committed precursors of cDCs (pre-cDCs). Pre-cDCs enter lymph nodes through and migrate along high endothelial venules and later disperse and integrate into the DC network. Further cDC development involves cell division, which is controlled in part by regulatory T cells and fms-like tyrosine kinase receptor-3.

publication date

  • April 17, 2009



  • Academic Article



  • eng

PubMed Central ID

  • PMC2803315

PubMed ID

  • 19286519

Additional Document Info

start page

  • 392

end page

  • 7


  • 324


  • 5925