Extended-release glipizide overdose presenting with delayed hypoglycemia and treated with subcutaneous octreotide Academic Article uri icon


MeSH Major

  • Gastrointestinal Agents
  • Glipizide
  • Hyperinsulinism
  • Hypoglycemia
  • Hypoglycemic Agents
  • Octreotide


  • The onset of symptomatic hypoglycemia in children with ingestions of second-generation sulfonylureas has never been documented to be later than 21 hours post-ingestion. We report a case with the longest known interval, 45 hours, between ingestion of a sulfonylurea and the onset of hypoglycemia requiring medical intervention. The hypoglycemia was severe and required multiple dextrose boluses in addition to continuous dextrose infusion for 36 hours. This patient was also treated with multiple doses of subcutaneous octreotide because of persistent hypoglycemia despite the above management. This case represents the first report of subcutaneous octreotide used as a treatment for pediatric hypoglycemia secondary to sulfonylurea exposure.

publication date

  • February 2009



  • Academic Article



  • eng

PubMed Central ID

  • PMC3810394

PubMed ID

  • 19449674

Additional Document Info

start page

  • 171

end page

  • 5


  • 22


  • 2