Circulating prostate tumor cells detected by Reverse transcription-PCR in men with localized or castration-refractory prostate cancer: Concordance with CellSearch assay and association with bone metastases and with survival
Academic Article
Overview
MeSH Major
Bone Neoplasms
Neoplastic Cells, Circulating
Orchiectomy
Prostatic Neoplasms
Reverse Transcriptase Polymerase Chain Reaction
abstract
Real-time RT-PCR assays of KLK mRNAs are highly concordant with CellSearch CTC results in patients with CRPC. KLK2/3-expressing CTCs are common in men with CRPC and bone metastases but are rare in patients with metastases diagnosed only in soft tissues and patients with localized cancer.
