Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support Academic Article uri icon

Overview

MeSH Major

  • Heart Failure
  • Heart-Assist Devices
  • MicroRNAs
  • Oligonucleotide Array Sequence Analysis
  • RNA, Messenger

abstract

  • These results show that miRs are more sensitive than mRNAs to the acute functional status of end-stage heart failure, consistent with important functions for regulated miRs in the myocardial response to stress. Combined miR and mRNA profiling may have superior potential as a diagnostic and prognostic test in end-stage cardiomyopathy.

publication date

  • March 10, 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2749457

Digital Object Identifier (DOI)

  • 10.1161/CIRCULATIONAHA.108.813576

PubMed ID

  • 19237659

Additional Document Info

start page

  • 1263

end page

  • 71

volume

  • 119

number

  • 9