NRH:Quinone oxidoreductase 2-deficient mice are highly susceptible to radiation-induced B-cell lymphomas Academic Article uri icon

Overview

MeSH Major

  • B-Lymphocytes
  • Gamma Rays
  • Lymphoma, B-Cell
  • Neoplasms, Radiation-Induced
  • Quinone Reductases

abstract

  • NQO2-null mice are highly susceptible to develop radiation-induced B-cell lymphomas. The lack of significant induction of p53 and Bax and decrease in B-cell apoptosis presumably contributed to the development of lymphomas. NQO2 functions as endogenous factor in prevention against radiation-induced B-cell lymphomas.

publication date

  • March 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3118578

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-08-1783

PubMed ID

  • 19223498

Additional Document Info

start page

  • 1534

end page

  • 42

volume

  • 15

number

  • 5