Fluorescence in situ hybridization analysis of circulating tumor cells in metastatic prostate cancer Academic Article uri icon

Overview

MeSH Major

  • In Situ Hybridization, Fluorescence
  • Neoplastic Cells, Circulating
  • Prostatic Neoplasms

abstract

  • The CTC isolated from our patient cohort present a very similar molecular cytogenetic profile to that reported for late-stage tumors and show that FISH analysis of CTC can be a valuable, noninvasive surrogate for routine tumor profiling. That as many as 50% of these patients have substantial amplification of the AR locus indicates that androgen signaling continues to play an important role in late-stage prostate cancer.

publication date

  • March 15, 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2875199

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-08-2036

PubMed ID

  • 19276271

Additional Document Info

start page

  • 2091

end page

  • 7

volume

  • 15

number

  • 6