Fluorescence in situ hybridization analysis of circulating tumor cells in metastatic prostate cancer
In Situ Hybridization, Fluorescence
Neoplastic Cells, Circulating
The CTC isolated from our patient cohort present a very similar molecular cytogenetic profile to that reported for late-stage tumors and show that FISH analysis of CTC can be a valuable, noninvasive surrogate for routine tumor profiling. That as many as 50% of these patients have substantial amplification of the AR locus indicates that androgen signaling continues to play an important role in late-stage prostate cancer.