The prognostic value of cardiopulmonary exercise testing in idiopathic pulmonary fibrosis. Academic Article uri icon

Overview

MeSH

  • Aged
  • Exercise Tolerance
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Logistic Models
  • Male
  • Middle Aged
  • Oxygen
  • Oxygen Consumption
  • Predictive Value of Tests
  • Prognosis
  • Proportional Hazards Models
  • Retrospective Studies
  • Smoking

MeSH Major

  • Exercise Test
  • Pulmonary Fibrosis

abstract

  • Idiopathic pulmonary fibrosis (IPF) is characterized by progressive dyspnea, impaired gas exchange, and ultimate mortality. To test the hypothesis that maximal oxygen uptake during cardiopulmonary exercise testing at baseline and with short-term longitudinal measures would predict mortality in patients with idiopathic pulmonary fibrosis. Data from 117 patients with IPF and longitudinal cardiopulmonary exercise tests were examined retrospectively. Survival was calculated from the date of the first cardiopulmonary exercise test. Patients with baseline maximal oxygen uptake less than 8.3 ml/kg/min had an increased risk of death (n = 8; hazard ratio, 3.24; 95% confidence interval, 1.10-9.56; P = 0.03) after adjusting for age, gender, smoking status, baseline forced vital capacity, and baseline diffusion capacity for carbon monoxide. We were unable to define a unit change in maximal oxygen uptake that predicted survival in our cohort. We conclude that a threshold maximal oxygen uptake of 8.3 ml/kg/min during cardiopulmonary exercise testing at baseline adds prognostic information for patients with IPF.

publication date

  • March 1, 2009

has subject area

  • Aged
  • Exercise Test
  • Exercise Tolerance
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Logistic Models
  • Male
  • Middle Aged
  • Oxygen
  • Oxygen Consumption
  • Predictive Value of Tests
  • Prognosis
  • Proportional Hazards Models
  • Pulmonary Fibrosis
  • Retrospective Studies
  • Smoking

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2648909

Digital Object Identifier (DOI)

  • 10.1164/rccm.200802-241OC

PubMed ID

  • 19074597

Additional Document Info

start page

  • 402

end page

  • 407

volume

  • 179

number

  • 5