Genetic Control of Wayward Pluripotent Stem Cells and Their Progeny after Transplantation Academic Article uri icon


MeSH Major

  • Cell Differentiation
  • Neoplastic Stem Cells
  • Pluripotent Stem Cells
  • Stem Cell Transplantation
  • Transplantation Conditioning


  • The proliferative capacity of pluripotent stem cells and their progeny brings a unique aspect to therapeutics, in that once a transplant is initiated the therapist no longer has control of the therapy. In the context of the recent FDA approval of a human ESC trial and report of a neuronal-stem-cell-derived tumor in a human trial, strategies need to be developed to control wayward pluripotent stem cells. Here, we focus on one approach: direct genetic modification of the cells prior to transplantation with genes that can prevent the adverse events and/or eliminate the transplanted cells and their progeny.

publication date

  • April 3, 2009



  • Academic Article



  • eng

PubMed Central ID

  • PMC3254150

Digital Object Identifier (DOI)

  • 10.1016/j.stem.2009.03.010

PubMed ID

  • 19341619

Additional Document Info

start page

  • 289

end page

  • 300


  • 4


  • 4