Predictive Value of the Differential Expression of the Urokinase Plasminogen Activation Axis in Radical Prostatectomy Patients Academic Article uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • Neoplasm Recurrence, Local
  • Prostatectomy
  • Prostatic Neoplasms
  • Receptors, Urokinase Plasminogen Activator

abstract

  • Overexpression of both uPA and PAI-1 is associated with adverse pathologic features and higher risk of overall and aggressive disease recurrence in men treated with radical prostatectomy for clinically localized prostate cancer. After validation, these markers may be useful in selecting patients most likely to benefit from adjuvant therapy. These markers should also be considered for addition into postoperative prediction tools.

publication date

  • May 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.eururo.2008.06.054

PubMed ID

  • 18585843

Additional Document Info

start page

  • 1124

end page

  • 33

volume

  • 55

number

  • 5