Frontolimbic function and cortisol reactivity in response to emotional stimuli Academic Article uri icon


MeSH Major

  • Emotions
  • Frontal Lobe
  • Hydrocortisone
  • Limbic System
  • Saliva
  • Visual Perception


  • Frontolimbic structures involved in fear conditioning have also been associated with hypothalamic-pituitary-adrenal (HPA)-axis modulation, including amygdaloid, hippocampal, and ventromedial prefrontal cortex regions. Although HPA-axis function and endocrine changes have been investigated in the context of stress provocation, much research has not been conducted using functional neuroimaging in the study of the HPA axis and frontolimbic function in response to emotional stimuli. Using functional magnetic resonance imaging, the association of blood-oxygen-level dependent signal with salivary cortisol in response to an emotional visual scene paradigm was investigated, with prescan and postscan salivary cortisol analyzed as a covariate of interest during specific conditions. Cortisol reactivity to the paradigm was positively associated with amygdalar and hippocampal activity and negatively associated with ventromedial prefrontal cortex activity in conditions involving emotional imagery.

publication date

  • March 4, 2009



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1097/WNR.0b013e328326a031

PubMed ID

  • 19225430

Additional Document Info

start page

  • 429

end page

  • 34


  • 20


  • 4