Tryptophan degradation in irritable bowel syndrome: Evidence of indoleamine 2,3-dioxygenase activation in a male cohort Academic Article uri icon

Overview

MeSH Major

  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Irritable Bowel Syndrome
  • Tryptophan

abstract

  • These findings suggest that the activity of IDO, the immunoresponsive enzyme which is responsible for the degradation of tryptophan along this pathway, is enhanced in IBS patients relative to controls. This study provides novel evidence for an immune-mediated degradation of tryptophan in a male IBS population and identifies the kynurenine pathway as a potential source of biomarkers in this debilitating condition.

publication date

  • January 20, 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2648992

Digital Object Identifier (DOI)

  • 10.1186/1471-230X-9-6

PubMed ID

  • 19154614

Additional Document Info

start page

  • 6

volume

  • 9