Accelerating stem cell proliferation by down-regulation of cell cycle regulator p21 Academic Article uri icon

Overview

MeSH Major

  • Cyclin-Dependent Kinase Inhibitor p21
  • Mesenchymal Stromal Cells
  • Protein Kinase Inhibitors

abstract

  • Transient inhibition of the cell cycle regulator p21 results in significant acceleration of mesenchymal stem cell proliferation without promoting spontaneous cellular differentiation. Exposure to differentiation medium results in increased cellular differentiation toward the osteoblast and fat lineage. Manipulation of cell cycle regulators may represent a novel means by which stem cell proliferation can be accelerated, thereby decreasing the time required for scaffold synthesis in tissue engineering.

publication date

  • September 18, 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1097/PRS.0b013e318191c82b

PubMed ID

  • 19182674

Additional Document Info

start page

  • 149S

end page

  • 57S

volume

  • 123

number

  • SUPPL.2S