Shigella Targets the Mitochondrial Checkpoint of Programmed Necrosis Article uri icon

Overview

MeSH Major

  • Apoptosis
  • Epithelial Cells
  • Mitochondria
  • Shigella

abstract

  • In nonmyeloid cells, Shigella hijacks the mitochondrial checkpoint of cell death, thereby inducing a regulated form of necrosis depending on Bnip3 and cyclophilin D. Carneiro et al. (2009) describe the interplay between this program and a prosurvival response transmitted via the Nod1/Rip2/NF-kappaB/Bcl-2 axis, which determines the fate of infected cells.

publication date

  • February 19, 2009

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.chom.2009.01.002

Additional Document Info

start page

  • 107

end page

  • 9

volume

  • 5

number

  • 2