Comparative effects of natural and synthetic diallyl disulfide on apoptosis of human breast-cancer MCF-7 cells. Academic Article Article uri icon

Overview

MeSH

  • Cell Cycle
  • Cell Line, Tumor
  • Flow Cytometry
  • Humans

MeSH Major

  • Allyl Compounds
  • Antineoplastic Agents
  • Apoptosis
  • Biological Products
  • Breast Neoplasms
  • Disulfides

abstract

  • The apoptotic effects of natural (n-) and synthetic (s-) DADS (diallyl disulfide; 3,3'-thiobisprop-1-ene) on human breast-cancer MCF-7 cells were investigated in vitro. 5-Fu (5-fluorouracil) and CTX (cyclophosphamide; Cytoxan) were used as comparative control anticancer agents. After MCF-7 cells had been treated with the drugs, cell viability, morphological change, apoptosis and changes in the cell cycle were measured. The results indicated that s- and n-DADS had similar cytotoxicities towards human breast-cancer MCF-7 cells and showed dose-dependent and time-dependent inhibitory effects. Morphological observations and flow-cytometric results showed that the four drugs (s-DADS, n-DADS, CTX and 5-Fu) induced apoptosis in MCF-7 cells to different extents. The apoptotic effects of s- and n-DADS were superior to those of 5-Fu and CTX.

publication date

  • February 2009

has subject area

  • Allyl Compounds
  • Antineoplastic Agents
  • Apoptosis
  • Biological Products
  • Breast Neoplasms
  • Cell Cycle
  • Cell Line, Tumor
  • Disulfides
  • Flow Cytometry
  • Humans

Research

keywords

  • Comparative Study
  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1042/BA20070242

PubMed ID

  • 18289126

Additional Document Info

start page

  • 113

end page

  • 119

volume

  • 52

number

  • Pt 2