Renal disease in systemic lupus erythematosus with emphasis on classification of lupus glomerulonephritis advances and implications Review uri icon

Overview

MeSH Major

  • Lupus Erythematosus, Systemic
  • Lupus Nephritis

abstract

  • The International Society of Nephrology/ Renal Pathology Society-sponsored Classification of Lupus Glomerulonephritis proposes standardized definitions of the various pathologic findings, describes clinically relevant lesions, incorporates prognostic parameters, and recommends a uniform way of reporting the renal biopsy findings. Lupus glomerulonephritis is divided into 6 classes primarily based on the morphologic lesions, extent and severity of the involvement, immune complex deposition, and activity and chronicity. Special emphasis is laid on describing qualitative as well as quantitative morphologic data and to include the accompanying tubulointerstitial disease and different vascular lesions, which have prognostic and therapeutic significance. This classification is intended to facilitate a higher degree of reproducibility, resulting in better patient care and more effective future clinical and translational research. Renal biopsy findings in systemic lupus erythematosus add new and independent parameters of prognostic significance to established clinical and genetic factors.

publication date

  • February 2009

Research

keywords

  • Review

Identity

Language

  • eng

PubMed ID

  • 19195967

Additional Document Info

start page

  • 233

end page

  • 48

volume

  • 133

number

  • 2