The role of progenitor cells in the development of intimal hyperplasia. Review uri icon

Overview

MeSH

  • Animals
  • Cell Differentiation
  • Cell Movement
  • Disease Models, Animal
  • Endothelial Cells
  • Hematopoietic Stem Cells
  • Humans
  • Hyperplasia
  • Mesenchymal Stromal Cells
  • Myocytes, Smooth Muscle

MeSH Major

  • Arteries
  • Bone Marrow Cells
  • Cell Proliferation
  • Stem Cells
  • Tunica Intima

abstract

  • Recent evidence has suggested that bone marrow derived progenitor cells may contribute to the development of intimal hyperplasia after arterial injury, a process that classically has been believed to involve extracellular matrix deposition and the migration and proliferation of cells within the arterial wall. The first studies demonstrating the existence of bone marrow derived cells in the neointima employed mouse models of arterial injury in conjunction with whole bone marrow transplant. Later studies have shown specifically that bone marrow derived hematopoietic or mesenchymal stem cells can be recruited to the neointima and differentiate into smooth muscle cells or endothelial cells. Although the data vary widely depending on different animal models of arterial injury and methods of labeling bone marrow derived cells, it appears that progenitor cells do indeed contribute to intimal hyperplasia, at least in mouse models of arterial injury. To date, signaling molecules such as c-kit and c-kit ligand, and stromal derived factor-1alpha, in addition to matrix metalloproteinase-9, have emerged as critical factors that recruit progenitor cells to sites of arterial injury. While much progress has been made, several tasks remain, including the need for a more in-depth understanding of the mechanisms underlying progenitor cell recruitment, characterization of the involved progenitor cells, and finally validation that the observations made in these mouse models of disease are also applicable to human arterial restenosis.

publication date

  • February 2009

has subject area

  • Animals
  • Arteries
  • Bone Marrow Cells
  • Cell Differentiation
  • Cell Movement
  • Cell Proliferation
  • Disease Models, Animal
  • Endothelial Cells
  • Hematopoietic Stem Cells
  • Humans
  • Hyperplasia
  • Mesenchymal Stromal Cells
  • Myocytes, Smooth Muscle
  • Stem Cells
  • Tunica Intima

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC2924205

Digital Object Identifier (DOI)

  • 10.1016/j.jvs.2008.07.060

PubMed ID

  • 18945574

Additional Document Info

start page

  • 502

end page

  • 510

volume

  • 49

number

  • 2