Resistance to annexin A5 anticoagulant activity: A thrombogenic mechanism for the antiphospholipid syndrome Review uri icon

Overview

MeSH Major

  • Annexin A5
  • Antibodies, Antiphospholipid
  • Antiphospholipid Syndrome
  • Binding Sites, Antibody
  • Phospholipids
  • Thrombosis

abstract

  • The phospholipid binding protein, annexin A5 (AnxA5), has potent anticoagulant properties that result from its forming 2-dimensional crystals over phospholipids, blocking the availability of the phospholipids for critical coagulation enzyme reactions. This article reviews the evidence that antiphospholipid antibodies can disrupt this anticoagulant shield and unmask thrombogenic anionic phospholipids, which may thereby contribute to thrombosis in patients with the antiphospholipid syndrome (APS). This mechanism for thrombosis in APS can be monitored with coagulation assays for resistance to anticoagulant activity of AnxA5.

publication date

  • December 2008

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1177/0961203308095029

PubMed ID

  • 18827057

Additional Document Info

start page

  • 922

end page

  • 30

volume

  • 17

number

  • 10