IFN-γ down-regulates Secretoglobin 3A1 gene expression Academic Article uri icon

Overview

MeSH Major

  • Gene Expression
  • Interferon-gamma
  • Proteins

abstract

  • STAT1 mediates Interferon (IFN)-dependent positive and negative regulation of inflammatory gene expression in lung. In this study, we examined the effect of IFN-gamma on the expression of SCGB3A1 which is thought to play crucial roles in inflammation and epithelial cell differentiation in lung. We found that expression of SCGB3A1 was down-regulated by IFN-gamma in a time- and dose-dependent manner in the murine transformed Clara Cells (mtCC) line. IFN-gamma induced the phosphorylation of STAT1, which binds to a STAT-binding element (SBE) in the SCGB3A1 gene promoter, leading to decreased transcriptional activation of this gene.

publication date

  • February 20, 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2792195

Digital Object Identifier (DOI)

  • 10.1016/j.bbrc.2008.12.187

PubMed ID

  • 19135978

Additional Document Info

start page

  • 964

end page

  • 8

volume

  • 379

number

  • 4