A constrained non-rigid registration algorithm for use in prostate image-guided radiotherapy Conference Paper uri icon


MeSH Major

  • Antineoplastic Combined Chemotherapy Protocols
  • Astrocytoma
  • Brain Neoplasms
  • Oligodendroglioma


  • A constrained non-rigid registration (CNRR) algorithm for use in updating prostate external beam image-guided radiotherapy treatment plans is presented in this paper. The developed algorithm is based on a multi-resolution cubic B-spline FFD transformation and has been tested and verified using 3D CT images from 10 sets of real patient data acquired from 4 different patients on different treatment days. The registration can be constrained to any combination of the prostate, rectum, bladder, pelvis, left femur, and right femur. The CNRR was tested with 5 different combinations of constraints and each test significantly outperformed both rigid and non-rigid registration at aligning constrained bones and critical organs. The CNRR was then used to update the treatment plans to account for articulated, rigid bone motion and non-rigid organ deformation. Each updated treatment plan outperformed the original treatment plan by increasing radiation dosage to the prostate and lowering radiation dosage to the rectum and bladder. © 2008 Springer-Verlag Berlin Heidelberg.

publication date

  • December 2008



  • Conference Paper


Digital Object Identifier (DOI)

  • 10.1007/978-3-540-85988-8_93

Additional Document Info

start page

  • 780

end page

  • 788


  • 5241 LNCS


  • PART 1