Neuronal release of proBDNF Academic Article uri icon

Overview

MeSH Major

  • Brain-Derived Neurotrophic Factor
  • Neurons
  • Protein Precursors

abstract

  • Pro-brain-derived neurotrophic factor (proBDNF) and mature BDNF utilize distinct receptors to mediate divergent neuronal actions. Using new tools to quantitate endogenous BDNF isoforms, we found that mouse neurons secrete both proBDNF and mature BDNF. The highest levels of proBDNF and p75 were observed perinatally and declined, but were still detectable, in adulthood. Thus, BDNF actions are developmentally regulated by secretion of proBDNF or mature BDNF and by local expression of p75 and TrkB.

publication date

  • February 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2737352

Digital Object Identifier (DOI)

  • 10.1038/nn.2244

PubMed ID

  • 19136973

Additional Document Info

start page

  • 113

end page

  • 5

volume

  • 12

number

  • 2