Visceral pleural invasion: Pathologic criteria and use of elastic stains: Proposal for the 7th edition of the TNM classification for lung cancer Review uri icon


MeSH Major

  • Carcinoma, Non-Small-Cell Lung
  • Lung Neoplasms
  • Neoplasm Staging
  • Pleural Neoplasms
  • Staining and Labeling


  • Based on the currently available data, we propose that the next tumor, node, metastasis (TNM) revision by International Union Against Cancer and American Joint Committee on Cancer define VPI as invasion beyond the elastic layer (PL1) including invasion to the visceral pleural surface (PL2). The abbreviation PL for pleura is recommended rather than P to avoid confusion with the existing use of p (pathologic) TNM in distinction from c (clinical) TNM. We also recommend that elastic stains be used in cases when the distinction between PL0 and PL1 is not clear based on evaluation of hematoxylin and eosin sections.

publication date

  • December 2008



  • Review



  • eng

Digital Object Identifier (DOI)

  • 10.1097/JTO.0b013e31818e0d9f

PubMed ID

  • 19057261

Additional Document Info

start page

  • 1384

end page

  • 90


  • 3


  • 12