BRCA germline mutations in Jewish patients with pancreatic adenocarcinoma Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma
  • Genes, BRCA1
  • Genes, BRCA2
  • Jews
  • Mutation
  • Pancreatic Neoplasms

abstract

  • Founder mutations for BRCA1 and BRCA2 were identified in 5.5% of Ashkenazi patients operated on for PAC. BRCA2 mutations were more prevalent than documented by population studies. Consistent with previous reports, BRCA2 mutations are associated with an increased risk of PAC.

publication date

  • January 20, 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3657622

Digital Object Identifier (DOI)

  • 10.1200/JCO.2008.18.5546

PubMed ID

  • 19064968

Additional Document Info

start page

  • 433

end page

  • 8

volume

  • 27

number

  • 3