Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients Academic Article uri icon

Overview

MeSH Major

  • Antiviral Agents
  • Drug Resistance, Viral
  • Hepacivirus
  • Hepatitis C
  • Mutation
  • Protease Inhibitors

abstract

  • Naturally occurring dominant STAT-C resistance mutations are common in treatment-naïve patients infected with HCV genotype 1. Their influence on treatment outcome should further be characterized to evaluate possible benefits of drug resistance testing for individual tailoring of drug combinations when treatment options are limited due to previous nonresponse to peginterferon and ribavirin.

authors

publication date

  • December 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2645896

Digital Object Identifier (DOI)

  • 10.1002/hep.22549

PubMed ID

  • 19026009

Additional Document Info

start page

  • 1769

end page

  • 78

volume

  • 48

number

  • 6