Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress Academic Article uri icon

Overview

MeSH Major

  • Apoptosis
  • Endoplasmic Reticulum
  • Forkhead Transcription Factors
  • Macrophages, Peritoneal

abstract

  • Decreased Akt and increased FoxO transcription factor activity during the endoplasmic reticulum stress response leads to increased apoptosis of insulin-resistant macrophages. FoxOs may have a dual cellular function, resulting in either proapoptotic or anti-inflammatory effects in an endoplasmic reticulum stress-modulated manner. In the complex plaque milieu, the ultimate effect is likely to be an increase in macrophage apoptosis, plaque inflammation, and destabilization.

publication date

  • November 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2570393

Digital Object Identifier (DOI)

  • 10.2337/db08-0520

PubMed ID

  • 18728232

Additional Document Info

start page

  • 2967

end page

  • 76

volume

  • 57

number

  • 11