Electrophysiological consequences of acute regional ischemia/reperfusion in neonatal rat ventricular myocyte monolayers Academic Article uri icon

Overview

MeSH Major

  • Electrophysiology
  • Heart Ventricles
  • Muscle Cells
  • Myocardial Reperfusion Injury

abstract

  • Acute regional ischemia/reperfusion in neonatal rat ventricular myocyte monolayers recapitulates electrophysiological alterations and arrhythmias similar to those observed during acute coronary occlusion/reperfusion in intact hearts. During early reperfusion, slow recovery from connexin-43 dephosphorylation leads to persistent CV slowing, creating a highly arrhythmogenic substrate.

publication date

  • December 2, 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2730415

Digital Object Identifier (DOI)

  • 10.1161/CIRCULATIONAHA.108.789149

PubMed ID

  • 19015404

Additional Document Info

start page

  • 2330

end page

  • 7

volume

  • 118

number

  • 23