Targeted delivery of therapeutics to endothelium. Review uri icon

Overview

MeSH

  • Animals
  • Antigens, Differentiation
  • Edema
  • Hemorrhage
  • Humans
  • Metabolic Diseases
  • Neoplasms

MeSH Major

  • Drug Carriers
  • Endothelium, Vascular
  • Ischemia
  • Oxidative Stress
  • Thrombosis

abstract

  • The endothelium is a target for therapeutic and diagnostic interventions in a plethora of human disease conditions including ischemia, inflammation, edema, oxidative stress, thrombosis and hemorrhage, and metabolic and oncological diseases. Unfortunately, drugs have no affinity to the endothelium, thereby limiting the localization, timing, specificity, safety, and effectiveness of therapeutic interventions. Molecular determinants on the surface of resting and pathologically altered endothelial cells, including cell adhesion molecules, peptidases, and receptors involved in endocytosis, can be used for drug delivery to the endothelial surface and into intracellular compartments. Drug delivery platforms such as protein conjugates, recombinant fusion constructs, targeted liposomes, and stealth polymer carriers have been designed to target drugs and imaging agents to these determinants. We review endothelial target determinants and drug delivery systems, describe parameters that control the binding of drug carriers to the endothelium, and provide examples of the endothelial targeting of therapeutic enzymes designed for the treatment of acute vascular disorders including ischemia, oxidative stress, inflammation, and thrombosis.

publication date

  • January 2009

has subject area

  • Animals
  • Antigens, Differentiation
  • Drug Carriers
  • Edema
  • Endothelium, Vascular
  • Hemorrhage
  • Humans
  • Ischemia
  • Metabolic Diseases
  • Neoplasms
  • Oxidative Stress
  • Thrombosis

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3074598

Digital Object Identifier (DOI)

  • 10.1007/s00441-008-0676-7

PubMed ID

  • 18815813

Additional Document Info

start page

  • 283

end page

  • 300

volume

  • 335

number

  • 1