Network analysis of temporal effects of intermittent and sustained hypoxia on rat lungs Academic Article uri icon

Overview

MeSH Major

  • Gene Regulatory Networks
  • Hypoxia
  • Lung

abstract

  • intermittent and sustained hypoxia induced distinct gene expression patterns in rat lungs. The functional characteristics of genes activated by these two distinct perturbations suggest their roles in the downstream physiological effects of intermittent and sustained hypoxia. Our results demonstrate the discovery potential of applying systems biology approaches to the understanding of mechanisms underlying hypoxic lung response.

publication date

  • December 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2604785

Digital Object Identifier (DOI)

  • 10.1152/physiolgenomics.00258.2007

PubMed ID

  • 18826996

Additional Document Info

start page

  • 24

end page

  • 34

volume

  • 36

number

  • 1