Impact of molecular staging methods in primary melanoma: Reverse-Transcriptase Polymerase Chain Reaction (RT-PCR) of ultrasound-guided aspirate of the sentinel node does not improve diagnostic accuracy, but RT-PCR of Peripheral blood does predict survival Academic Article uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • Biopsy, Fine-Needle
  • Lymph Nodes
  • Melanoma
  • Monophenol Monooxygenase
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sentinel Lymph Node Biopsy
  • Ultrasonography, Interventional

abstract

  • US-FNAC is highly accurate and eliminates the need for SLNB in 16% of all SLNB patients. RT-PCR of the aspirate or excised SN does not improve sensitivity or specificity. RT-PCR of blood samples predicts DFS and OS.

publication date

  • December 10, 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2007.13.7653

PubMed ID

  • 18981467

Additional Document Info

start page

  • 5742

end page

  • 7

volume

  • 26

number

  • 35