Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations. Academic Article uri icon

Overview

MeSH

  • Adult
  • Alaska
  • Body Composition
  • Body Mass Index
  • Epistasis, Genetic
  • Female
  • Haplotypes
  • Humans
  • Male
  • Middle Aged
  • New York City
  • Phenotype
  • Sequence Analysis, DNA
  • Skinfold Thickness
  • Waist Circumference

MeSH Major

  • Adiposity
  • European Continental Ancestry Group
  • Ghrelin
  • Inuits
  • Polymorphism, Single Nucleotide

abstract

  • Human adiposity is highly heritable, but few of the genes that predispose to obesity in most humans are known. We tested candidate genes in pathways related to food intake and energy expenditure for association with measures of adiposity. We studied 355 genetic variants in 30 candidate genes in 7 molecular pathways related to obesity in two groups of adult subjects: 1,982 unrelated European Americans living in the New York metropolitan area drawn from the extremes of their body mass index (BMI) distribution and 593 related Yup'ik Eskimos living in rural Alaska characterized for BMI, body composition, waist circumference, and skin fold thicknesses. Data were analyzed by using a mixed model in conjunction with a false discovery rate (FDR) procedure to correct for multiple testing. After correcting for multiple testing, two single nucleotide polymorphisms (SNPs) in Ghrelin (GHRL) (rs35682 and rs35683) were associated with BMI in the New York European Americans. This association was not replicated in the Yup'ik participants. There was no evidence for gene x gene interactions among genes within the same molecular pathway after adjusting for multiple testing via FDR control procedure. Genetic variation in GHRL may have a modest impact on BMI in European Americans.

publication date

  • 2009

has subject area

  • Adiposity
  • Adult
  • Alaska
  • Body Composition
  • Body Mass Index
  • Epistasis, Genetic
  • European Continental Ancestry Group
  • Female
  • Ghrelin
  • Haplotypes
  • Humans
  • Inuits
  • Male
  • Middle Aged
  • New York City
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Sequence Analysis, DNA
  • Skinfold Thickness
  • Waist Circumference

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2715950

Digital Object Identifier (DOI)

  • 10.1159/000181158

PubMed ID

  • 19077438

Additional Document Info

start page

  • 193

end page

  • 205

volume

  • 67

number

  • 3